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	Provedor de dados Biol. Res. (2) Autor Carreño,Leandro J (1) FAROUDI,MUSTAPHA (1) FAVIER,BENOIT (1) Kalergis,Alexis M (1) Llanos,Carolina (1) VALITUTTI,SALVATORE (1) ZARU,ROSSANA (1) Mais... Palavra-chave Immunological synapse (2) Autoimmunity (1) Dendritic cells (1) Signal transduction (1) T cell antigen receptor (1) T cells (1) Tolerance (1) Mais... Tipo do documento Journal article (2) Ano 2011 (1) 2002 (1) País Chile (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity Biol. Res. Llanos,Carolina; Carreño,Leandro J; Kalergis,Alexis M. Under healthy conditions, there is a balance between tolerance to self-tissue constituents and immunity against foreign antigens. Autoimmunity diseases (AD) take place when that equilibrium is disrupted and the immune response is directed to self-antigens, leading to injury or destruction of host tissues. The mechanisms conducing to the loss of immune tolerance remain largely unknown. The recent appearance of biological therapies has contributed to significant reduction in morbidity. However, currently available therapies are associated with important side effects and work only as palliative treatments. Dendritic cells (DCs) have emerged as key players in developing and maintaining adaptive immunity due to their capacity to prime and modulate T cell... Tipo: Journal article Palavras-chave: Dendritic cells; T cells; Immunological synapse; Autoimmunity; Tolerance. Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100007 New insights to the functional role of the T cell-Antigen Presenting Cell immunological synapse Biol. Res. FAROUDI,MUSTAPHA; ZARU,ROSSANA; FAVIER,BENOIT; VALITUTTI,SALVATORE. Three innovative and complementary morphological approaches were employed to study the T cell/antigen presenting cell (APC) interaction: (i) high resolution three-dimensional confocal microscopy of the T cell-APC contact site; (ii) time lapse video recording in living T cells of [Ca2+]I and changes in distribution of various GFP fusion proteins with TCR/CD3-zetacomplex associated- and other signaling components; (iii) measurement of lateral TCR mobility and that of recruited signaling components using techniques based on fluorescence recovery after photo-bleaching. These approaches were combined with biochemical and functional experiments to investigate two principal issues: (A) Recruitment and the three-dimensional arrangement of receptors and signaling... Tipo: Journal article Palavras-chave: T cell antigen receptor; Immunological synapse; T cell antigen receptor; Signal transduction. Ano: 2002 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200004 Registros recuperados: 2 Primeira ... 1 ... Última

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